Jaar: 2011
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Blood and Beyond: Improving properties of human virus-specific CD8+ T cells for adoptive immunotherapy.
T cells are important for our immune defense against pathogens and tumors. Whereas a fraction of T cells continuously circulates through the body, other populations take up permanent residency in organs such as lung, skin and gut. Recent work from…
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Epigenetics in neutrophil biology: from transcriptome to granulocyte transfusions.
Our study provides patterns of specific “programs” (epigenetic profiles) to explain the unique steps of differentiation from an early white blood cell type (i.e. promyelocyte) onto the last step of maturation into a cell with a segmented multilobular nucleus that…
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Mesenchymal stromal cells and hematopoietic stem cell transplantation; from bench to bedside.
Mesenchymal stromal cells (MSC) can be obtained from various tissues in our body, e.g. in the bone marrow were they support hematopoiesis. Transplantation of cultured MSC is promising and is increasingly applied for various purposes, for instance after hematopoietic stem…
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Mesenchymal stromal cells and hematopoietic stem cell transplantation; from bench to bedside.
Mesenchymal stromal cells (MSC) can be obtained from various tissues in our body, e.g. in the bone marrow were they support hematopoiesis. Transplantation of cultured MSC is promising and is increasingly applied for various purposes, for instance after hematopoietic stem…
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Next generation sequencing in extremes to identify functional genetic variants affecting red blood cell volume
We have three types of blood cells: red cells to carry oxygen to our tissues, white cells to fight infections and platelets to prevent bleeding. Red cells are the most abundant cells in the blood and retrieve in the lungs…
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Regulation of functional differences between cord blood versus adult peripheral blood innate cells.
In this project we focused on a small subset of immune cells, the so called innate lymphoid cells, which are best studied when derived from human tonsils. These cells have been described to be important for maintaining tissue integrity, in…
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Selective mRNA translation controls erythropoiesis; regulation and function of the RNA-binding protein Csde1.
The Csde1 protein contains seven RNA-binding domains, called cold-shock domains. Hence its name Cold shock domain E1. The Csde1 protein is widely expressed, but erythroblasts express 100-fold more Csde1 compared to precursors of other hematopoietic lineages. This suggests that Csde1…
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The effects of Hypoxia-inducible factor 1α (Hif-1α) on the development of hemogenic endothelium, hematopoietic stem cells and the supportive microenvironment.
Low oxygen concentrations within various tissues of the embryo and adult play a physiological role in the development and growth of the stem cells for the blood system. In our LSBR funded-studies we examined the mouse embryo to determine whether…