Jaar: 2014
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Assembling the molecular machinery of coagulation: learning from the adaptive evolution of snake venom proteins.
Blood clotting protects humans and animals against injury-induced blood loss. Clotting occurs through a cascade of proteolytic reactions that convert an inactive protease (zymogen) to an active protease. Most of the reactions only occur when the cofactor-protease complexes assemble on…
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Redesigning coagulation factor VIII; Repairing an evolutionary mistake.
The process of blood clotting involves a series of enzymatic reactions in the blood. The protein factor VIII (FVIII) is indispensable in this process in which it markedly enhances the activity of the enzyme factor IX (FIX). The importance of…
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Role of RBC adhesion molecules in immune adherence clearance.
Immune adherence clearance is the process by which red blood cells bind bacteria and other pathogens in the blood stream and deliver them to the spleen where they are taken up and degraded by a specialized cell type, the macrophage.…
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The protective role of innate lymphoid cells (ILC) after hematopoietic stem cell transplantation.
Transplantation of healthy donor stem cells is often needed to cure patients with malignant hematologic diseases such as acute leukemia or lymphoma. While such transplantation is very effective, it can also be very dangerous. With the transplantation of stem cells,…
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The protective role of innate lymphoid cells (ILC) after hematopoietic stem cell transplantation.
Transplantation of healthy donor stem cells is often needed to cure patients with malignant hematologic diseases such as acute leukemia or lymphoma. While such transplantation is very effective, it can also be very dangerous. With the transplantation of stem cells,…
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Towards routine HPA-screening in pregnancy to prevent FNAIT: Assessing disease burden, optimising risk group selection and Safety of IVIg Treatment.
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is the most common cause of thrombocytopenia in otherwise healthy newborns. During pregnancy, maternal immunization against unknown, paternally derived, antigens on fetal blood cells can occur. Alloantibodies against HPA-1a are the most commonly involved…
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Transgenerational T cells: a cellular form of maternal care after birth with therapeutic potential in allogeneic stem cell therapy.
T cells are used in various therapies for the treatment of patients. For instance, the presence of T cells is an important factor in stem cell therapy of leukemia patients. Sometimes, umbilical cord blood is used as a source of…