Jaar: 2016
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Border control at the vessel wall: The endothelium as customs official for leukocyte crossing.
A significant development in this project was the vessel on a chip. This has resulted in several fruitful collaborations, not only national but also international. The work was published in J Cell Science (https://doi.org/10.1242/jcs.258690), with an additional editorial interview with…
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How to prevent unwanted antibodies; regulation of plasma cell fate by the dynamic interplay between specific B cells and follicular T-helper cells.
After blood transfusion patients regularly form antibodies against donor blood cells (alloantibodies). This causes undesired side effects and becomes a major problem when donors need to receive multiple transfusions. Alloimmunisation occurs through activation of B cells by parts of the…
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IgG Fab glycosylation: a novel mediator of humoral tolerance.
Our immune system protects against infection by invading pathogens. B cells are an important part of the immune system. These cells can recognize pathogens and make specific antibodies. To protect our bodies against a range of pathogens, a wide repertoire…
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Intercellular communication and immunomodulatory activities of platelet microvesicles in vascular inflammation.
Blood platelets are small cell fragments that do not have a nucleus and are essential for the prevention of blood loss. Upon injury, platelets rapidly form blood clots. This leads to the sealing of the wound and to the arrest…
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Repurposing CRISPR/Cas9 for targeted demethylation of the gamma-globin promoters.
β-hemoglobinopathies (β-thalassemias and sickle cell disease) are the most common genetic disorders in the human population. Sustained expression of γ-globin, the β-like globin expressed during the fetal stages of development, is a major mitigating factor for disease severity. Worldwide, over…
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Universal and tissue-tailored gene programs of resident memory lymphocytes.
Our bodies are frequently exposed to pathogens, including viruses and bacteria, which enter the body through barrier tissues, such as the skin, lungs, and intestine. In response to these infections, specialized immune cells are formed in the barrier tissues, so…
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Universal and tissue-tailored gene programs of resident memory lymphocytes.
Our bodies are frequently exposed to pathogens, including viruses and bacteria, which enter the body through barrier tissues, such as the skin, lungs, and intestine. In response to these infections, specialized immune cells are formed in the barrier tissues, so…