Jaar: 2019
-
Cytokine network architecture at the endothelial interface: The whole is greater than the sum of its parts.
A recording of the layman summary during the PhD defense can be found here (in Dutch): https://youtu.be/bmUTMpuSKGQ All the blood vessels in our body are lined with a single thin layer of specialized cells called endothelial cells. Sitting right between…
-
Innate lymphoid cells to the barriers in allogeneic hematopoietic cell transplantation patients.
Transplantation with donor immune cells is often an important part of the treatment for patients with acute leukemia or other diseases of the bone marrow. The donor immune cells create a new immune system, which subsequently eliminates the patient’s leukemia…
-
Mechanistic dissection of clinically relevant allo-antibodies.
In this project we set out to investigate several leads that could identify which patients with Human Platelet Antigen-1a (HPA-1a) antibodies are at high risk of developing Fetal and neonatal alloimmune thrombocytopenia (FNAIT). Previously our work had suggested afucosylation of…
-
Role of platelet glucose metabolism in hemostasis and inflammation.
Platelets are essential for hemostasis (a process that stops bleeding), but also play an important role in the regulation of inflammation. Activation of platelets requires energy, which can be generated by metabolism of substrates such as glucose and lipids within…
-
Transfusion-associated circulatory overload (TACO) – a breathtaking syndrome.
Transfusion-associated circulatory overload (TACO) is one of the most serious complications of blood transfusion worldwide, associated with significant morbidity and mortality. This research focused on improving diagnosis, understanding underlying mechanisms, and developing strategies to prevent TACO. Nationwide surveys among clinicians…
-
Transfusion-associated circulatory overload (TACO) – a breathtaking syndrome.
Transfusion-associated circulatory overload (TACO) is the leading cause of transfusion related morbidity and mortality. The underlying mechanism for onset of TACO is unknown. The current proposal aims through a translational approach to understand the mechanisms involved in the onset of…