Jaar: 2020
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Conformational regulation of ADAMTS13 in immune trombotic thrombocytopenic purpura.
Immune Thrombotic Thrombocytopenic Purpura (iTTP) is a rare life-threatening bleeding disorder with an annual incidence of 2-6 cases per million per year. Patients with iTTP suffer from an accumulation of platelets on uncleaved von Willebrand Factor (VWF) multimers. Normally these…
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E-cadherin controls erythropoiesis; a novel avenue to treat anemia.
Patients with bone marrow disorders can develop an impaired production of healthy red blood cells, resulting in anemia. As a result, these patients require regular blood transfusions. However, this can lead to serious health complications due to elevated iron levels,…
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E-cadherin controls erythropoiesis; a novel avenue to treat anemia.
Each second the bone marrow produces millions of red blood cells (RBCs). Aging-associated bone marrow diseases disturb this process leading to anemia thereby generating significant health issues. Chronic anemic patients receive blood transfusions that temporarily restore their RBC counts to…
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New determinant of Weibel-Palade body shape and Von Willebrand factor trafficking within ER-Golgi SNARE networks.
In the event of a bleeding a blood vessel immediately responds by locally releasing hemostatic proteins into the circulation. The endothelial cells forming the innerlining of the vessel secrete von Willebrand factor (VWF), a protein that will form a sticky…